2002 |
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Torkel Klingberg, Hans Forssberg, Helena Westerberg Training of Working Memory in Children With ADHD Journal Article Journal of Clinical and Experimental Neuropsychology, 24 (6), pp. 781–791, 2002, ISSN: 1380-3395. @article{Klingberg2002, title = {Training of Working Memory in Children With ADHD}, author = {Torkel Klingberg and Hans Forssberg and Helena Westerberg}, url = {https://www.tandfonline.com/doi/full/10.1076/jcen.24.6.781.8395}, doi = {10.1076/jcen.24.6.781.8395}, issn = {1380-3395}, year = {2002}, date = {2002-09-01}, journal = {Journal of Clinical and Experimental Neuropsychology}, volume = {24}, number = {6}, pages = {781--791}, abstract = {Purpose: Oral mucositis is a common and severe complication of head and neck radiation therapy. Evaluating the progression and severity of radiation-induced oral mucositis is an important aspect of treatment because oral mucositis often debilitates the patient's quality of life and may interrupt or change the cancer treatment. Localized, time-dependent tissue changes that occur during radiation may be conducive to the development of a clinical model of mucosal tissue damage. Materials and Methods: The secretion of biochemical markers, such as human alpha-defensins, was examined in the oral mucosa from patients receiving radiation therapy using the ProteinChip array, surface-enhanced laser desorption/ionization technology (Ciphergen Biosystems Inc, Fremont, CA) combined with time-of-flight mass spectrometry. This method has also proven to be effective and feasible in detecting and measuring changes of alpha-defensins in a small amount of biological fluids. Results: The concentration of the human alpha-defensins measured in the exudates from the surface in the field of developing oral mucositis lesions changed during the development and healing processes. Conclusion: This method may provide the means to assess oral mucositis during development and resolution and to assist in developing an understanding of the pathogenesis of the condition. In addition, this method may provide a means of assessing developing tissue damage and lead to new approaches to prevent and treat oral mucositis in cancer therapy.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Purpose: Oral mucositis is a common and severe complication of head and neck radiation therapy. Evaluating the progression and severity of radiation-induced oral mucositis is an important aspect of treatment because oral mucositis often debilitates the patient's quality of life and may interrupt or change the cancer treatment. Localized, time-dependent tissue changes that occur during radiation may be conducive to the development of a clinical model of mucosal tissue damage. Materials and Methods: The secretion of biochemical markers, such as human alpha-defensins, was examined in the oral mucosa from patients receiving radiation therapy using the ProteinChip array, surface-enhanced laser desorption/ionization technology (Ciphergen Biosystems Inc, Fremont, CA) combined with time-of-flight mass spectrometry. This method has also proven to be effective and feasible in detecting and measuring changes of alpha-defensins in a small amount of biological fluids. Results: The concentration of the human alpha-defensins measured in the exudates from the surface in the field of developing oral mucositis lesions changed during the development and healing processes. Conclusion: This method may provide the means to assess oral mucositis during development and resolution and to assist in developing an understanding of the pathogenesis of the condition. In addition, this method may provide a means of assessing developing tissue damage and lead to new approaches to prevent and treat oral mucositis in cancer therapy. | |
2002 |
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Training of Working Memory in Children With ADHD Journal Article Journal of Clinical and Experimental Neuropsychology, 24 (6), pp. 781–791, 2002, ISSN: 1380-3395. | |