2014 |
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Sissela Bergman Nutley, Fahimeh Darki, Torkel Klingberg Music practice is associated with development of working memory during childhood and adolescence Journal Article Frontiers in Human Neuroscience, 7 (January), pp. 1–9, 2014. @article{BergmanNutley2014, title = {Music practice is associated with development of working memory during childhood and adolescence}, author = {Sissela {Bergman Nutley} and Fahimeh Darki and Torkel Klingberg}, doi = {10.3389/fnhum.2013.00926}, year = {2014}, date = {2014-01-01}, journal = {Frontiers in Human Neuroscience}, volume = {7}, number = {January}, pages = {1--9}, abstract = {Practicing a musical instrument is associated with cognitive benefits and structural brain changes in correlational and interventional trials; however, the effect of musical training on cognition during childhood is still unclear. In this longitudinal study of child development we analyzed the association between musical practice and performance on reasoning, processing speed and working memory (WM) during development. Subjects (n = 352) between the ages of 6 and 25 years participated in neuropsychological assessments and neuroimaging investigations (n = 64) on two or three occasions, 2 years apart. Mixed model regression showed that musical practice had an overall positive association with WM capacity (visuo-spatial WM}, keywords = {}, pubstate = {published}, tppubtype = {article} } Practicing a musical instrument is associated with cognitive benefits and structural brain changes in correlational and interventional trials; however, the effect of musical training on cognition during childhood is still unclear. In this longitudinal study of child development we analyzed the association between musical practice and performance on reasoning, processing speed and working memory (WM) during development. Subjects (n = 352) between the ages of 6 and 25 years participated in neuropsychological assessments and neuroimaging investigations (n = 64) on two or three occasions, 2 years apart. Mixed model regression showed that musical practice had an overall positive association with WM capacity (visuo-spatial WM | |
2010 |
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Stina Söderqvist, Fiona McNab, Myriam Peyrard-Janvid, Hans Matsson, Keith Humphreys, Juha Kere, Torkel Klingberg, Stina Sderqvist, Fiona McNab, Myriam Peyrard-Janvid, Hans Matsson, Keith Humphreys, Juha Kere, Torkel Klingberg The SNAP25 Gene Is Linked to Working Memory Capacity and Maturation of the Posterior Cingulate Cortex During Childhood Journal Article Biological Psychiatry, 68 (12), pp. 1120–1125, 2010, ISSN: 0006-3223. @article{Soderqvist2010, title = {The SNAP25 Gene Is Linked to Working Memory Capacity and Maturation of the Posterior Cingulate Cortex During Childhood}, author = {Stina Söderqvist and Fiona McNab and Myriam Peyrard-Janvid and Hans Matsson and Keith Humphreys and Juha Kere and Torkel Klingberg and Stina Sderqvist and Fiona McNab and Myriam Peyrard-Janvid and Hans Matsson and Keith Humphreys and Juha Kere and Torkel Klingberg}, url = {http://dx.doi.org/10.1016/j.biopsych.2010.07.036 https://www.sciencedirect.com/science/article/pii/S0006322310008851#sec7}, doi = {10.1016/J.BIOPSYCH.2010.07.036}, issn = {0006-3223}, year = {2010}, date = {2010-12-01}, journal = {Biological Psychiatry}, volume = {68}, number = {12}, pages = {1120--1125}, publisher = {Elsevier}, abstract = {BACKGROUND Working memory (WM) is the ability to retain task relevant information. This ability is important for a wide range of cognitive tasks, and WM deficits are a central cognitive impairment in neurodevelopment disorders such as attention-deficit/hyperactivity disorder (ADHD). Although WM capacity is known to be highly heritable, most genes involved remain unidentified. METHODS Single nucleotide polymorphisms in genes previously associated with cognitive functions or ADHD were selected for genotyping. Associations of these with WM tasks were investigated in a community sample of 330 children and young adults. One single nucleotide polymorphisms was also investigated in an independent sample of 88 4-year-old children. Furthermore, association between brain structure and activity, as measured by magnetic resonance imaging techniques, and single nucleotide polymorphisms alleles were estimated in 88 participants. RESULTS Genotype at rs363039, located in the gene coding for synaptosomal-associated protein, 25 kDa (SNAP25) was associated to WM capacity in both samples. Associations in the community sample were also found with measures of other cognitive functions. In addition, this polymorphism affected the gray matter and brain activity in the posterior cingulate cortex, an area included in the so-called default mode network previously correlated to regulation of attention and hypothesized to be implicated in ADHD. CONCLUSIONS A novel gene–brain–behavior network was identified in which a genotype located in SNAP25 affects WM and has age-dependent effects on both brain structure and brain activity. Identifying such networks could be a key to better understanding cognitive development as well as some of its disorders.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND Working memory (WM) is the ability to retain task relevant information. This ability is important for a wide range of cognitive tasks, and WM deficits are a central cognitive impairment in neurodevelopment disorders such as attention-deficit/hyperactivity disorder (ADHD). Although WM capacity is known to be highly heritable, most genes involved remain unidentified. METHODS Single nucleotide polymorphisms in genes previously associated with cognitive functions or ADHD were selected for genotyping. Associations of these with WM tasks were investigated in a community sample of 330 children and young adults. One single nucleotide polymorphisms was also investigated in an independent sample of 88 4-year-old children. Furthermore, association between brain structure and activity, as measured by magnetic resonance imaging techniques, and single nucleotide polymorphisms alleles were estimated in 88 participants. RESULTS Genotype at rs363039, located in the gene coding for synaptosomal-associated protein, 25 kDa (SNAP25) was associated to WM capacity in both samples. Associations in the community sample were also found with measures of other cognitive functions. In addition, this polymorphism affected the gray matter and brain activity in the posterior cingulate cortex, an area included in the so-called default mode network previously correlated to regulation of attention and hypothesized to be implicated in ADHD. CONCLUSIONS A novel gene–brain–behavior network was identified in which a genotype located in SNAP25 affects WM and has age-dependent effects on both brain structure and brain activity. Identifying such networks could be a key to better understanding cognitive development as well as some of its disorders. |
2014 |
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Music practice is associated with development of working memory during childhood and adolescence Journal Article Frontiers in Human Neuroscience, 7 (January), pp. 1–9, 2014. | |
2010 |
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The SNAP25 Gene Is Linked to Working Memory Capacity and Maturation of the Posterior Cingulate Cortex During Childhood Journal Article Biological Psychiatry, 68 (12), pp. 1120–1125, 2010, ISSN: 0006-3223. |