Publications

@article{Constantinidis2016,
title = {The neuroscience of working memory capacity and training},
author = {Christos Constantinidis and Torkel Klingberg},
url = {http://dx.doi.org/10.1038/nrn.2016.43 http://www.nature.com/articles/nrn.2016.43},
doi = {10.1038/nrn.2016.43},
issn = {1471-003X},
year = {2016},
date = {2016-07-01},
journal = {Nature Reviews Neuroscience},
volume = {17},
number = {7},
pages = {438--449},
publisher = {Nature Publishing Group},
abstract = {Working memory (WM) — the ability to maintain and manipulate information over a period of seconds — is a key cognitive skill. Constantinidis and Klingberg discuss non-human-primate, computational-modelling and human-neuroimaging studies that examine the neural bases of WM and training-induced enhancements of WM capacity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Klingberg2006,
title = {Development of a superior frontal–intraparietal network for visuo-spatial working memory},
author = {Torkel Klingberg},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0028393205003830},
doi = {10.1016/j.neuropsychologia.2005.11.019},
issn = {00283932},
year = {2006},
date = {2006-01-01},
journal = {Neuropsychologia},
volume = {44},
number = {11},
pages = {2171--2177},
abstract = {Working memory capacity increases throughout childhood and adolescence, which is important for the development of a wide range of cognitive abilities, including complex reasoning. The spatial-span task, in which subjects retain information about the order and position of a number of objects, is a sensitive task to measure development of spatial working memory. This review considers results from previous neuroimaging studies investigating the neural correlates of this development. Older children and adolescents, with higher capacity, have been found to have higher brain activity in the intraparietal cortex and in the posterior part of the superior frontal sulcus, during the performance of working memory tasks. The structural maturation of white matter has been investigated by diffusion tensor magnetic resonance imaging (DTI). This has revealed several regions in the frontal lobes in which white matter maturation is correlated with the development of working memory. Among these is a superior fronto-parietal white matter region, located close to the grey matter regions that are implicated in the development of working memory. Furthermore, the degree of white matter maturation is positively correlated with the degree of cortical activation in the frontal and parietal regions. This suggests that during childhood and adolescence, there is development of networks related to specific cognitive functions, such as visuo-spatial working memory. These networks not only consist of cortical areas but also the white matter tracts connecting them. For visuo-spatial working memory, this network could consist of the superior frontal and intraparietal cortex. textcopyright 2005 Elsevier Ltd. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Olesen2003,
title = {Combined analysis of DTI and fMRI data reveals a joint maturation of white and grey matter in a fronto-parietal network},
author = {Pernille J Olesen and Zoltan Nagy and Helena Westerberg and Torkel Klingberg},
url = {https://linkinghub.elsevier.com/retrieve/pii/S092664100300212X},
doi = {10.1016/j.cogbrainres.2003.09.003},
issn = {09266410},
year = {2003},
date = {2003-12-01},
journal = {Cognitive Brain Research},
volume = {18},
number = {1},
pages = {48--57},
abstract = {The aim of this study was to explore whether there are networks of regions where maturation of white matter and changes in brain activity show similar developmental trends during childhood. In a previous study, we showed that during childhood, grey matter activity increases in frontal and parietal regions. We hypothesized that this would be mediated by maturation of white matter. Twenty-three healthy children aged 8-18 years were investigated. Brain activity was measured using the blood oxygen level-dependent (BOLD) contrast with functional magnetic resonance imaging (fMRI) during performance of a working memory (WM) task. White matter microstructure was investigated using diffusion tensor imaging (DTI). Based on the DTI data, we calculated fractional anisotropy (FA), an indicator of myelination and axon thickness. Prior to scanning, WM score was evaluated. WM score correlated independently with FA values and BOLD response in several regions. FA values and BOLD response were extracted for each subject from the peak voxels of these regions. The FA values were used as covariates in an additional BOLD analysis to find brain regions where FA values and BOLD response correlated. Conversely, the BOLD response values were used as covariates in an additional FA analysis. In several cortical and sub-cortical regions, there were positive correlations between maturation of white matter and increased brain activity. Specifically, and consistent with our hypothesis, we found that FA values in fronto-parietal white matter correlated with BOLD response in closely located grey matter in the superior frontal sulcus and inferior parietal lobe, areas that could form a functional network underlying working memory function. textcopyright 2003 Elsevier B.V. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}