Publications

@article{Darki2014,
title = {DCDC2 Polymorphism Is Associated with Left Temporoparietal Gray and White Matter Structures during Development},
author = {F Darki and M Peyrard-Janvid and H Matsson and J Kere and T Klingberg},
doi = {10.1523/jneurosci.1216-14.2014},
issn = {0270-6474},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neuroscience},
volume = {34},
number = {43},
pages = {14455--14462},
abstract = {textcopyright 2014 the authors. Three genes, DYX1C1, DCDC2, and KIAA0319, have been previously associated with dyslexia, neuronal migration, and ciliary function. Three polymorphisms within these genes, rs3743204 (DYX1C1), rs793842 (DCDC2), and rs6935076 (KIAA0319) have also been linked to normal variability of left temporoparietal white matter volume connecting the middle temporal cortex to the angular and supramarginal gyri. Here, we assessed whether these polymorphisms are also related to the cortical thickness of the associated regions during childhood development using a longitudinal dataset of 76 randomly selected children and young adults who were scanned up to three times each, 2 years apart. rs793842 in DCDC2 was significantly associated with the thickness of left angular and supramarginal gyri as well as the left lateral occipital cortex. The cortex was significantly thicker for T-allele carriers, who also had lower white matter volume and lower reading comprehension scores. There was a negative correlation between white matter volume and cortical thickness, but only white matter volume predicted reading comprehension 2 years after scanning. These results show how normal variability in reading comprehension is related to gene, white matter volume, and cortical thickness in the inferior parietal lobe. Possibly, the variability of gray and white matter structures could both be related to the role of DCDC2 in ciliary function, which affects both neuronal migration and axonal outgrowth.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Darki2012,
title = {Three Dyslexia Susceptibility Genes, DYX1C1, DCDC2, and KIAA0319, Affect Temporo-Parietal White Matter Structure},
author = {Fahimeh Darki and Myriam Peyrard-Janvid and Hans Matsson and Juha Kere and Torkel Klingberg},
url = {https://www.sciencedirect.com/science/article/pii/S0006322312004453 http://linkinghub.elsevier.com/retrieve/pii/S0006322312004453 http://dx.doi.org/10.1016/j.biopsych.2012.05.008},
doi = {10.1016/j.biopsych.2012.05.008},
issn = {00063223},
year = {2012},
date = {2012-10-01},
journal = {Biological Psychiatry},
volume = {72},
number = {8},
pages = {671--676},
publisher = {Elsevier},
abstract = {BACKGROUND Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. METHODS We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population. RESULTS We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. CONCLUSIONS The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}