Publications

@article{Darki2015,
title = {The role of fronto-parietal and fronto-striatal networks in the development of working memory: A longitudinal study},
author = {Fahimeh Darki and Torkel Klingberg},
url = {https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bht352},
doi = {10.1093/cercor/bht352},
issn = {14602199},
year = {2015},
date = {2015-06-01},
journal = {Cerebral Cortex},
volume = {25},
number = {6},
pages = {1587--1595},
abstract = {The increase in working memory (WM) capacity is an important part of cognitive development during childhood and adolescence. Cross-sectional analyses have associated this development with higher activity, thinner cortex, and white matter maturation in fronto-parietal networks. However, there is still a lack of longitudinal data showing the dynamics of this development and the role of subcortical structures. We included 89 individuals, aged 6-25 years, who were scanned 1-3 times at 2-year intervals. Functional magnetic resonance imaging (fMRI) was used to identify activated areas in superior frontal, intraparietal cortices, and caudate nucleus during performance on a visuo-spatial WM task. Probabilistic tractography determined the anatomical pathways between these regions. In the cross-sectional analysis, WM capacity correlated with activity in frontal and parietal regions, cortical thickness in parietal cortex, and white matter structure [both fractional anisotropy (FA) and white matter volume] of fronto-parietal and fronto-striatal tracts. However, in the longitudinal analysis, FA in white matter tracts and activity in caudate predicted future WM capacity. The results show a dynamic of neural networks underlying WM development in which cortical activity and structure relate to current capacity, while white matter tracts and caudate activity predict future WM capacity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}