Publications

@article{McNab2009,
title = {Changes in cortical dopamine D1 receptor binding associated with cognitive training},
author = {Fiona McNab and Andrea Varrone and Lars Farde and Aurelija Jucaite and Paulina Bystritsky and Hans Forssberg and Torkel Klingberg and Fiona McNab and Andrea Varrone and Lars Farde and Aurelija Jucaite and Paulina Bystritsky and Hans Forssberg and Torkel Klingberg},
url = {http://www.sciencemag.org/cgi/doi/10.1126/science.1166102%5Cnpapers3://publication/doi/10.1126/science.1166102 http://www.ncbi.nlm.nih.gov/pubmed/19197069 http://www.sciencemag.org/cgi/doi/10.1126/science.1166102},
doi = {10.1126/science.1166102},
issn = {00368075},
year = {2009},
date = {2009-02-01},
journal = {Science},
volume = {323},
number = {5915},
pages = {800--802},
abstract = {Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Westerberg2007,
title = {Changes in cortical activity after training of working memory - a single-subject analysis},
author = {Helena Westerberg and Torkel Klingberg},
doi = {10.1016/j.physbeh.2007.05.041},
issn = {00319384},
year = {2007},
date = {2007-01-01},
journal = {Physiology and Behavior},
volume = {92},
number = {1-2},
pages = {186--192},
abstract = {Working memory (WM) capacity is an important factor for a wide range of cognitive skills. This capacity has generally been assumed to be fixed. However, recent studies have suggested that WM can be improved by intensive, computerized training [Klingberg T, Fernell E, Olesen P, Johnson M, Gustafsson P, Dahlström K, et al. Computerized training of working memory in children with ADHD - a randomized, controlled trial. J Am Acad Child Adolesc Psych 2005;44:177--86]. A recent study by Olesen, Westerberg and Klingberg [Olesen P, Westerberg H, Klingberg T. Increased prefrontal and parietal brain activity after training of working memory. Nat Neurosci 2004;7:75--9] showed that group analysis of brain activity data show increases in prefrontal and parietal cortices after WM training. In the present study we performed single-subject analysis of the changes in brain activity after five weeks of training. Three young, healthy adults participated in the study. On two separate days before practice and during one day after practice, brain activity was measured with functional magnetic resonance imaging (fMRI) during performance of a WM and a baseline task. Practice on the WM tasks gradually improved performance and this effect lasted several months. The effect of practice also generalized to improve performance on a non-trained WM task and a reasoning task. After training, WM-related brain activity was significantly increased in the middle and inferior frontal gyrus. The changes in activity were not due to activations of any additional area that was not activated before training. Instead, the changes could best be described by small increases in the extent of the area of activated cortex. The effect of training of WM is thus in several respects similar to the changes in the functional map observed in primate studies of skill learning, although the physiological effect in WM training is located in the prefrontal association cortex. textcopyright 2007 Elsevier Inc. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}