2018 |
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F Nemmi, C Nymberg, F Darki, T Banaschewski, A L W Bokde, C Büchel, H Flor, V Frouin, H Garavan, P Gowland, A Heinz, J -L Martinot, F Nees, T Paus, M N Smolka, T W Robbins, G Schumann, Torkel Klingberg Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence Journal Article Developmental Cognitive Neuroscience, 30 (February), pp. 191–199, 2018, ISSN: 18789293. @article{Nemmi2018b, title = {Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence}, author = {F Nemmi and C Nymberg and F Darki and T Banaschewski and A L W Bokde and C Büchel and H Flor and V Frouin and H Garavan and P Gowland and A Heinz and J -L Martinot and F Nees and T Paus and M N Smolka and T W Robbins and G Schumann and Torkel Klingberg}, url = {https://doi.org/10.1016/j.dcn.2018.03.006 https://linkinghub.elsevier.com/retrieve/pii/S1878929317301536}, doi = {10.1016/j.dcn.2018.03.006}, issn = {18789293}, year = {2018}, date = {2018-04-01}, journal = {Developmental Cognitive Neuroscience}, volume = {30}, number = {February}, pages = {191--199}, publisher = {Elsevier}, abstract = {There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood. Dopamine-related genes, striatal activation and morphology have been associated with increased WM capacity after training. Here we tested the hypothesis that these factors would also explain some of the inter-individual differences in the rate of WM development. We measured WM performance in 487 healthy subjects twice: at age 14 and 19. At age 14 subjects underwent a structural MRI scan, and genotyping of five single nucleotide polymorphisms (SNPs) in or close to the dopamine genes DRD2, DAT-1 and COMT, which have previously been associated with gains in WM after WM training. We then analyzed which biological factors predicted the rate of increase in WM between ages 14 and 19. We found a significant interaction between putamen size and DAT1/SLC6A3 rs40184 polymorphism, such that TC heterozygotes with a larger putamen at age 14 showed greater WM improvement at age 19. The effect of the DAT1 polymorphism on WM development was exerted in interaction with striatal morphology. These results suggest that development of WM partially share neuro-physiological mechanism with training-induced plasticity.}, keywords = {}, pubstate = {published}, tppubtype = {article} } There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood. Dopamine-related genes, striatal activation and morphology have been associated with increased WM capacity after training. Here we tested the hypothesis that these factors would also explain some of the inter-individual differences in the rate of WM development. We measured WM performance in 487 healthy subjects twice: at age 14 and 19. At age 14 subjects underwent a structural MRI scan, and genotyping of five single nucleotide polymorphisms (SNPs) in or close to the dopamine genes DRD2, DAT-1 and COMT, which have previously been associated with gains in WM after WM training. We then analyzed which biological factors predicted the rate of increase in WM between ages 14 and 19. We found a significant interaction between putamen size and DAT1/SLC6A3 rs40184 polymorphism, such that TC heterozygotes with a larger putamen at age 14 showed greater WM improvement at age 19. The effect of the DAT1 polymorphism on WM development was exerted in interaction with striatal morphology. These results suggest that development of WM partially share neuro-physiological mechanism with training-induced plasticity. | |
2012 |
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T Ziermans, I Dumontheil, C Roggeman, M Peyrard-Janvid, H Matsson, J Kere, T Klingberg Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development Journal Article Translational Psychiatry, 2 (2), pp. e85–9, 2012, ISSN: 21583188. @article{Ziermans2012, title = {Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development}, author = {T Ziermans and I Dumontheil and C Roggeman and M Peyrard-Janvid and H Matsson and J Kere and T Klingberg}, url = {http://dx.doi.org/10.1038/tp.2012.7}, doi = {10.1038/tp.2012.7}, issn = {21583188}, year = {2012}, date = {2012-01-01}, journal = {Translational Psychiatry}, volume = {2}, number = {2}, pages = {e85--9}, publisher = {Nature Publishing Group}, abstract = {A developmental increase in working memory capacity is an important part of cognitive development, and low working memory (WM) capacity is a risk factor for developing psychopathology. Brain activity represents a promising endophenotype for linking genes to behavior and for improving our understanding of the neurobiology of WM development. We investigated gene-brain-behavior relationships by focusing on 18 single-nucleotide polymorphisms (SNPs) located in six dopaminergic candidate genes (COMT, SLC6A3/DAT1, DBH, DRD4, DRD5, MAOA). Visuospatial WM (VSWM) brain activity, measured with functional magnetic resonance imaging, and VSWM capacity were assessed in a longitudinal study of typically developing children and adolescents. Behavioral problems were evaluated using the Child Behavior Checklist (CBCL). One SNP (rs6609257), located ~6.6 kb downstream of the monoamine oxidase A gene (MAOA) on human chromosome X, significantly affected brain activity in a network of frontal, parietal and occipital regions. Increased activity in this network, but not in caudate nucleus or anterior prefrontal regions, was correlated with VSWM capacity, which in turn predicted externalizing (aggressive/oppositional) symptoms, with higher WM capacity associated with fewer externalizing symptoms. There were no direct significant correlations between rs6609257 and behavioral symptoms. These results suggest a mediating role of WM brain activity and capacity in linking the MAOA gene to aggressive behavior during development.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A developmental increase in working memory capacity is an important part of cognitive development, and low working memory (WM) capacity is a risk factor for developing psychopathology. Brain activity represents a promising endophenotype for linking genes to behavior and for improving our understanding of the neurobiology of WM development. We investigated gene-brain-behavior relationships by focusing on 18 single-nucleotide polymorphisms (SNPs) located in six dopaminergic candidate genes (COMT, SLC6A3/DAT1, DBH, DRD4, DRD5, MAOA). Visuospatial WM (VSWM) brain activity, measured with functional magnetic resonance imaging, and VSWM capacity were assessed in a longitudinal study of typically developing children and adolescents. Behavioral problems were evaluated using the Child Behavior Checklist (CBCL). One SNP (rs6609257), located ~6.6 kb downstream of the monoamine oxidase A gene (MAOA) on human chromosome X, significantly affected brain activity in a network of frontal, parietal and occipital regions. Increased activity in this network, but not in caudate nucleus or anterior prefrontal regions, was correlated with VSWM capacity, which in turn predicted externalizing (aggressive/oppositional) symptoms, with higher WM capacity associated with fewer externalizing symptoms. There were no direct significant correlations between rs6609257 and behavioral symptoms. These results suggest a mediating role of WM brain activity and capacity in linking the MAOA gene to aggressive behavior during development. | |
Stina Söderqvist, Sissela Bergman Nutley, Myriam Peyrard-Janvid, Hans Matsson, Keith Humphreys, Juha Kere, Torkel Klingberg Dopamine, working memory, and training induced plasticity: Implications for developmental research Journal Article Developmental Psychology, 48 (3), pp. 836–843, 2012, ISSN: 00121649. @article{Soderqvist2012, title = {Dopamine, working memory, and training induced plasticity: Implications for developmental research}, author = {Stina Söderqvist and Sissela Bergman Nutley and Myriam Peyrard-Janvid and Hans Matsson and Keith Humphreys and Juha Kere and Torkel Klingberg}, doi = {10.1037/a0026179}, issn = {00121649}, year = {2012}, date = {2012-01-01}, journal = {Developmental Psychology}, volume = {48}, number = {3}, pages = {836--843}, abstract = {Cognitive deficits and particularly deficits in working memory (WM) capacity are common features in neuropsychiatric disorders. Understanding the underlying mechanisms through which WM capacity can be improved is therefore of great importance. Several lines of research indicate that dopamine plays an important role not only in WM function but also for improving WM capacity. For example, pharmacological interventions acting on the dopaminergic system, such as methylphenidate, improve WM performance. In addition, behavioral interventions for improving WM performance in the form of intensive computerized training have recently been associated with changes in dopamine receptor density. These two different means of improving WM performance--pharmacological and behavioral--are thus associated with similar biological mechanisms in the brain involving dopaminergic systems. This article reviews some of the evidence for the role of dopamine in WM functioning, in particular concerning the link to WM development and cognitive plasticity. Novel data are presented showing that variation in the dopamine transporter gene (DAT1) influences improvements in WM and fluid intelligence in preschool-age children following cognitive training. Our results emphasize the importance of the role of dopamine in determining cognitive plasticity.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Cognitive deficits and particularly deficits in working memory (WM) capacity are common features in neuropsychiatric disorders. Understanding the underlying mechanisms through which WM capacity can be improved is therefore of great importance. Several lines of research indicate that dopamine plays an important role not only in WM function but also for improving WM capacity. For example, pharmacological interventions acting on the dopaminergic system, such as methylphenidate, improve WM performance. In addition, behavioral interventions for improving WM performance in the form of intensive computerized training have recently been associated with changes in dopamine receptor density. These two different means of improving WM performance--pharmacological and behavioral--are thus associated with similar biological mechanisms in the brain involving dopaminergic systems. This article reviews some of the evidence for the role of dopamine in WM functioning, in particular concerning the link to WM development and cognitive plasticity. Novel data are presented showing that variation in the dopamine transporter gene (DAT1) influences improvements in WM and fluid intelligence in preschool-age children following cognitive training. Our results emphasize the importance of the role of dopamine in determining cognitive plasticity. | |
2009 |
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Fiona McNab, Andrea Varrone, Lars Farde, Aurelija Jucaite, Paulina Bystritsky, Hans Forssberg, Torkel Klingberg, Fiona McNab, Andrea Varrone, Lars Farde, Aurelija Jucaite, Paulina Bystritsky, Hans Forssberg, Torkel Klingberg Changes in cortical dopamine D1 receptor binding associated with cognitive training Journal Article Science, 323 (5915), pp. 800–802, 2009, ISSN: 00368075. @article{McNab2009, title = {Changes in cortical dopamine D1 receptor binding associated with cognitive training}, author = {Fiona McNab and Andrea Varrone and Lars Farde and Aurelija Jucaite and Paulina Bystritsky and Hans Forssberg and Torkel Klingberg and Fiona McNab and Andrea Varrone and Lars Farde and Aurelija Jucaite and Paulina Bystritsky and Hans Forssberg and Torkel Klingberg}, url = {http://www.sciencemag.org/cgi/doi/10.1126/science.1166102%5Cnpapers3://publication/doi/10.1126/science.1166102 http://www.ncbi.nlm.nih.gov/pubmed/19197069 http://www.sciencemag.org/cgi/doi/10.1126/science.1166102}, doi = {10.1126/science.1166102}, issn = {00368075}, year = {2009}, date = {2009-02-01}, journal = {Science}, volume = {323}, number = {5915}, pages = {800--802}, abstract = {Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo. |
2018 |
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Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence Journal Article Developmental Cognitive Neuroscience, 30 (February), pp. 191–199, 2018, ISSN: 18789293. | |
2012 |
|
Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development Journal Article Translational Psychiatry, 2 (2), pp. e85–9, 2012, ISSN: 21583188. | |
Dopamine, working memory, and training induced plasticity: Implications for developmental research Journal Article Developmental Psychology, 48 (3), pp. 836–843, 2012, ISSN: 00121649. | |
2009 |
|
Changes in cortical dopamine D1 receptor binding associated with cognitive training Journal Article Science, 323 (5915), pp. 800–802, 2009, ISSN: 00368075. |